r/Nootropics • • Jan 17 '26

Scientific Study Blocking mobile internet on smartphones improves sustained attention, mental health, and subjective well-being

Thumbnail pmc.ncbi.nlm.nih.gov
59 Upvotes

r/Nootropics • • 7h ago

Vendor Report/Q Phenibut & phenylpiracetam vendors in EU?

6 Upvotes

Hello,

I'm sorry if this has been asked before.

It has been like 3-4 years since i last used phenibut or phenylpiracetam and i used to order them from Nootropics Depot, but it seems like they do not sell them anymore.

Do you know of any good EU-based vendors with quality as close as possible to the above mentioned seller?

Preferably in powder form please, as i usually took a few grams of phenibut at once and 200mg of phenylpiracetam (separately).

Thank you and have a nice day.


r/Nootropics • • 1h ago

Discussion Creatine Previously Cured ADHD but now Gives Racing Thoughts/Anxiety/Strange Mental State?

• Upvotes

Hey,

So to keep it short, around 2 years ago I was taking about 1g of Creatine HCL (CON CRET) daily via powder and it literally completely cured my ADHD - was super crazy sharp mentally, could sit down and focus for hours and felt very dopanergic and really good.

However, I stopped all supplements since for some time, recently had tried to resume it but now gives me racing thoughts, intrusive thoughts, and just doesn't make me feel good at all. For reference this is Creatine HCL capsules (1 pill) and the effects happen within a few hours.

I'm wondering if Creatine had originally allowed for such a profound mental effect, is there anything similar with regards to biochemical pathways? Ideally they wouldn't be some sort of herbs but rather something found naturally - for longer term usage here.

For reference was on keto/raw primal/carnivore sort of diets for that time. ADHD was also cured on keto diet but this was unsustainable and caused very bad anxiety attacks.


r/Nootropics • • 9h ago

Seeking Advice Help after using Phenibut

3 Upvotes

Hello! I had to start using phenibut in september due to experiencing random tachycardia for no reason and thats what my family gp gave to stop it, but my regular tachycardia episodes didnt stop so i went to a cardiologist who upon hearing i use phenibut told me to not use it anymore considering the addiction it gives. so i stopped using it on saturday but have been experiencing withdrawal and my condition feels even worse, should i start using it again a little bit or call my gp and ask for help?

(for more insight if others wish to reply later, i’m a girl with many chronic illnesses and yes in eastern europe phenibut is used for anxiety disorders but i am not diagnosed sadly as it is a lengthy process, i drank 250-500mg a day for about a month)


r/Nootropics • • 14h ago

Seeking Advice Nootropic Shipment via netherlands

3 Upvotes

I’m considering ordering some supplements/research compounds from a vendor outside the EU
I’m considering shipping it to the Netherlands first via a package forwarder and then forwarding it to Austria since Dutch customs seems more relaxed

Has anyone recently ordered to an EU country using this route?
How strict is Dutch customs with these packages in practice and is it safe for packages like these to enter the EU through Netherlands?
Any experiences with forwarders that accept non EU packages?

I’m mainly trying to understand the real difference in how the two countries handle shipments. Any experiences are appreciated a lot


r/Nootropics • • 20h ago

Discussion Has anyone actually experienced an improvement in their social anxiety from taking nootropics?

9 Upvotes

I have tried multiple nootropics ashwagandha, L-theanine
kava etc only 2 seemed to have worked or at least made me feel a difference Kratom and phenibut any other actual nootropics? I know you are not supposed to feel a big effect like drugs or alcohol but the change is not even subtle with anything other than kratom or phenibut,


r/Nootropics • • 16h ago

Seeking Advice Sick after nsi 189 oral droplet

4 Upvotes

Took the 4mg recommended dose for nsi 189 for the first time today. Got incredibly sick and threw up, still feeling it.
Took it in the morning, liquid, held it in mouth under tongue for a lil and now it’s 4am and I’m waking up from a claustrophobic spinning sleep.
Did I do something wrong?


r/Nootropics • • 20h ago

Seeking Advice Seeking suggestions of nootropics in the US

6 Upvotes

Hi all,

I used to take piracetam and choline in another country, but it seems that they were not sold in the US (at least without a prescription).

I am seeking suggestions on what to take for memory, concentration, etc., but I want to buy it in a trustworthy store such as CVS or any other online store/pharmacy.


r/Nootropics • • 21h ago

Vendor Report/Q Tianeptine Sulfate Vendors in EU NSFW

4 Upvotes

Hey!

I would like to order Tianeptine Sulfate for treating anhedonia and depression and executive dysfunctions (because of AuDHD and Kratom Paw). I tried Wellbutrin and Brintellix however they made me severely dissociate and made my anhedonia and apathy worse. Now i would give Tianeptine Sulfate in low doses (3x12.5mg) a try but in the sulfate form if possible because of the longer half life.

I have no experience with zion pharma or any british vendors but that's all i could find since I'm situed in central eu. May you please help me find a valid vendor if possible?

Thank you guys


r/Nootropics • • 1d ago

Seeking Advice Am I off to the right start? Overwhelmed..

4 Upvotes

Have studied nootropics and supplements over the years and I think im ready to give it a try this time. Some basic info:

-27 year old man.
-regularly sleep 7-9 hours a night but am constantly fatigued and have very little focus or drive. I have been to two sleep studies and really have not been helped at all so trying this in the interim.
-I have a health ring that consistently shows i am getting the proper amount of sleep, but the majority being light sleep. My REM and deep sleep is consistently too low, which is in line with the sleep study findings.
-diagnosed with ADHD. Currently take adderall 10mg IR 1-2x a day. Also have a 200mg caffeine Celsius drink maybe 3x a week.

My main goals are improving focus/energy while also potentially improving sleep quality. I am trying to research and find good blends on nootropic depot for a stack. So far, I have been considering this:

For energy in the morning: 200 MG L-theanine, 100 MG caffeine, 5 MG creatine. Also have interest in Alcar, COQ10, L-taurine and alpha GPC. What dosage would you recommend? And what kind of creatine? Does it matter?

For sleep: B vitamins, magnesium glycinate have caught my eye. Not sure of dosage or other options.

Could be way off with the above, but would just really appreciate any specific stacks/blends and any dosage advice. Thank you all


r/Nootropics • • 1d ago

Seeking Advice Cyclazodone or DMAA or is there something better?

5 Upvotes

What do people recommend for a first time user?? I've been prescribed 90 mg of amp. But am looking for something new. Dmaa or cyclazodone? Or is there a more efficacious stim? I don't think I would be interested in bromantane. If I'm asking the wrong questions I imagine I'll be scorched for it... Just looking for something outside of amp


r/Nootropics • • 1d ago

Scientific Study Addy and selank? Safe to take?

6 Upvotes

My rat wqa without adhd meds awhile and got overwhelmed and needed the help. Rat stopped taking selank. Does anyone know if it’s safe to take both?


r/Nootropics • • 1d ago

Vendor Report/Q Legit? Im UK based and this is the only thing that pops up. any advice regarding quality?

Post image
8 Upvotes

seems good to me but would like to know if anyone has had this brand


r/Nootropics • • 1d ago

Discussion What would count as convincing evidence that a nootropic improves memory?

1 Upvotes

Full disclosure: I work with a supplement company, so I have a professional interest in this topic. I'm not recommending our products here. I'm interested in how we distinguish genuine cognitive effects from noise.

How difficult it is to evaluate claims about memory supplements? Before asking whether something works, it helps to define what "working" actually means.

Memory isn't a single ability. Working memory, episodic memory, verbal recall, and recognition are different processes. A substance that improves performance on one task might have no measurable effect on another. Improvements on a particular test also don't necessarily translate into better everyday memory.

Study design matters just as much as the outcome being measured. A few things I'd look for when evaluating a nootropic study:

  • A clearly defined outcome. Was the study testing working memory, delayed recall, or another specific ability? Was that outcome chosen before the results were analyzed?
  • An appropriate control group. Randomization, blinding, and a placebo control help reduce the influence of expectations and other confounding factors.
  • Reliable cognitive tests. Tests need adequate reliability and sensitivity to detect meaningful changes. Repeated testing can also produce practice effects, where participants improve because they're familiar with the task.
  • Adequate sample size and statistical analysis. Small studies can produce unstable results, and testing many outcomes increases the chance of finding a statistically significant result by chance. Effect sizes and confidence intervals matter, not just p-values.
  • Replication. An isolated positive study is less convincing than a finding reproduced by independent researchers.
  • Real-world relevance. A statistically significant change on a laboratory task doesn't automatically mean a noticeable improvement in daily functioning.

Placebo effects and expectations complicate things, too. Someone might genuinely feel sharper after taking a supplement, but subjective impressions alone can't establish that memory performance improved. The reverse is also possible: a person might experience a measurable benefit without noticing much difference subjectively.

There's another distinction worth making when comparing supplement formulations. Evidence that an ingredient has an effect doesn't establish that every formulation containing it works equally well. But evidence that a modified formulation changes absorption or another measurable property doesn't, by itself, demonstrate better memory. Ideally, you'd want a well-controlled head-to-head trial comparing the formulations on prespecified cognitive outcomes.

For personal tracking, using the same validated test under similar conditions and recording factors such as sleep, caffeine, and testing time can help identify patterns. However, self-experiments are exploratory: practice effects, day-to-day variability, and expectations can make the results difficult to interpret.

My takeaway is that the strongest evidence comes from well-designed human studies that measure a specific cognitive outcome, quantify the size and uncertainty of the effect, and reproduce the finding independently.

What do you consider the most convincing evidence for a nootropic's effect on memory: replicated clinical trials, improvements across multiple cognitive tests, or demonstrated benefits in everyday functioning?

(mods: please message me if I'm breaking any rules as I'm trying to stay compliant with them and not make any advertisements).


r/Nootropics • • 1d ago

Vendor Report/Q Does anyone have experience with Dr Grace Mitchel on Telegram?

0 Upvotes

I was DM'ed on Redit about this Telegram user and Just wondering if this is a trusted source to be buying nootropics from.


r/Nootropics • • 2d ago

Discussion Should I try SSRI's to treat anxiety?

16 Upvotes

I've tried a lot of things, nothing quite helped long-term. I'm tired of feeling a sense of dread when starting anything new, affecting my employment.

I have better periods and worse ones, but it's a persistent issue for me. I can't think of anything new to try to deal with this. I tried to push off this option for too long.


r/Nootropics • • 2d ago

Seeking Advice What to know about Selank and Semax?

5 Upvotes

I recently got my hands on a nasal spray containing 10 mg selank and 10 mg semax, I don't know much about nootropics/cognitive encanchers and wanted to know if these were safe and what dosage I should take & when. Thanks.


r/Nootropics • • 2d ago

Experience PRL-8-53 and THC... (Oops) NSFW

25 Upvotes

Just want to put this out there as interesting info, not a recommendation at all.
This will turn into a trip report of sorts. And as it was caused by nootropics I think it is relevant to this sub.

The setting: I had not taken PRL in about 3 weeks. I took 9 mg sublingually at 7am but didn't swallow it; I just spat out the rest due to some GI discomfort I had before.
It was my first time trying this method, so I was just seeing if it would still work. I honestly didn't notice much, maybe a slight change in mood and focus.

At about 9pm I decided to take some modafinil, as I needed to get work done. I took a low dose of 80 mg. Probably a coffee or two also.
Was completely fine all day, not hyperactive, no high heart rate, etc. But not as productive as I wanted.
Dinner was around 6pm, and I decided to go to bed early and took 0.25 mg melatonin (works for me).
And I thought, "Fk it, let's smoke some weed" it usually helps with deep sleep if used sparingly, loaded up the bowl with around .2 of a gram, but I did pop a small amount of kief on top.
Right after the first hit, I remember I took the PRL in the morning. I think—oh shit, oh well, not much I can do now...
It had been over 10h so I assumed it would be out of my system, plus the likely bad absorption, and I had also smoked on the tail end of modafinil with no issues.
My THC tolerance wasn't high but wasn't nothing, I had smoked maybe once in the prev week and about 8 times in the last 3 weeks.

Now for the interesting part. I had much, much more euphoria than normal; to me it was like when I smoked weed on methylphenidate, maybe even stronger.
I was in bed, and I was surprised by how stoned I was. Kinda worried but surprisingly zero anxiety.
I'm watching some YT video and decide to pop on a song and close my eyes, facing up at the ceiling.

This is where it gets trippy. I get full-on closed-eye visuals. It started as a bunch of colors/light and turned into an open a4 book about a meter away from me, behind it was a black void.
The book had drawings on it; they were black on a cream page, they moved like stop motion, and each page, which I saw, had a border, and within the border was a very complex matrix of drawings.
The drawing style for lack of a better word was like calligraphy, or the texture of a fountain pen.

Not photo realistic or anything but a WHOLE lot going on. Way too much to process in the 3 seconds before the pages would change.
To be honest I really can't see any of the details in my head now, but I did draw some the day after.

At the time what amazed me was how quickly my brain could come up with such complex art. I mean two full A4 pages every few seconds...
I ended up turning off the music halfway through and had the hum of the amp, which made it even clearer.
Really quite an amazing experience. Thankfully little adverse effects, maybe a little drowsy in the morning and less motivation the next few days.
A small benefit is that I started drawing again, my creativity seems to be stronger, like I'm being more expansive with my cooking and coffee prep for example.

If you made it this far- thank you!
Let me know what you think or if you had a similar experience.
Don't just call me reckless please, I am using nootropics for a reason- I was not looking for a high.


r/Nootropics • • 2d ago

Vendor Report/Q Noopept - where to source in the UK?

11 Upvotes

Hi.
Basically what it says. I've tried amazon and ebay, but no luck. Do you have a reliable source of it? I'm talking the pills (prefferable) 10mg or so, not a pure form etc

cheers!


r/Nootropics • • 3d ago

Discussion Isochroma (1977–2016): A Reconstruction of One of the Early Nootropics Underground's Most Unusual Self-Experimenters

50 Upvotes

Some of you will remember Isochroma, later Isochroma-Reborn: the international racetam price list, the Sunifiram discussions, the reports of up to 32.5 g of piracetam a day. His name was Jason Lalancette. He died on May 1, 2016, in Victoria, British Columbia, a little over ten years ago.

A few years ago, a user here wrote that Isochroma’s remarks about the saturation of orange sodium streetlights and the lack of “splendid dreams” described almost exactly his own piracetam experience, months after he had read them (comment). That is the kind of effect his writing had, and it is what made me start digging. After almost a year of reading, archiving and comparing material across Longecity, T-Nation, Bluelight, Reddit, Reveddit, Doom9, AVSForum, his blogs and abandoned websites, I’ve written it up (my own site):

Essay and archives

  • Full essay: Isochroma: Protocol of an Uninhabitable Life
  • Portal: his surviving websites, forums and projects
  • Corpus: searchable collection of his posts
  • Web Archive: preserved pages from his former websites
  • Animescenes Backup: archive of his anime screenshot collection
  • Poetry Collection: collected poems, verses and poetic passages from his writings
  • Protocols: collection of his documented self-experiments, substance regimens, dosages and physiological interventions.

On r/Nootropics, his death was reported in "Isochroma is dead". A few months later, u/IsochromasSuccessor, who knew him personally, published "Isochroma's Story", still the most detailed surviving biographical account and an important source for my research.

He believed he needed piracetam simply to function. He described longstanding fatigue, cognitive difficulties and physical limitations, and experienced piracetam as a profound change in what he could think, write and accomplish. At his peak, he reported taking up to 32.5 grams daily, divided into five doses. When his supply disappeared, he described falling back into a state he considered nearly unlivable. In one post, he compared himself to a prisoner counting the hours between doses: "It's a life sentence, with me as the judge, jury, warden and prisoner all wrapped into one."

His distinction between "Depletors" and "Replenishers" ran through much of his writing. Caffeine and conventional stimulants merely borrowed energy from the organism, he believed, while piracetam, fish oil, methylene blue and eventually artificial light could restore its underlying capacity to function. The distinction was biochemically crude, but it helps explain why he regarded his experiments as attempts at repair rather than ordinary cognitive enhancement.

He combined racetams with fish oil, methylene blue, DXM, cannabis and other compounds, recording changes in cognition, dreams, visual perception and sleep. Over time he developed his own tests, including an "edge test" for the apparent sharpness of high-contrast boundaries. He examined chrome surfaces, narrow lines and door cracks, borrowing terminology from video-processing algorithms such as WarpSharp. Elsewhere he wrote that Aniracetam, Coluracetam and Sunifiram were the only racetams that had a "heart", by which he meant a particular emotional quality of consciousness that he struggled to describe. He also recorded less welcome effects: irritability, impatience, altered sleep and increasingly risky behaviour. Some he understood as costs, others as changes his improved perception could compensate for ("So there is compensation.").

From private supply problem to public infrastructure. After a piracetam supply failure in 2008, he turned his private supplier list into an international racetam price list: nine compounds, hundreds of suppliers, prices, shipping costs, payment methods and availability. He updated it almost daily, sometimes several times a day. The date doubled as a version number ("December 18.7" meant the seventh upload that day). He later wrote that he had put thousands of hours into it.

Sunifiram. In March 2012, he wrote to Prof. Fulvio Gualtieri in Florence, whose group had developed Sunifiram and Unifiram. Gualtieri's 2015 review, Unifi nootropics from the lab to the web, quotes a correspondent identified only as "John Doe" who, with high probability, was Isochroma: he wanted to order 1 g of DM235 and asked whether he would be the first human to try it. Gualtieri warned him twice that neither pharmacokinetics nor toxicology were known. About a year later, Doe told the inventors that Sunifiram was now sold online, and wrote that their dream had come true. On Longecity, Isochroma cheered when user Q became the first forum member to try it ("One small step for Q, one giant leap for mankind"). Gualtieri saw it differently: the dream had been a medicine, not a street drug. How much Isochroma actually contributed to Sunifiram's market introduction can't be established, but the movement itself is confirmed from the inventors' side.

Phenylpiracetam Hydrazide. In 2011, Isochroma mentioned a BrainMeta post of his on Piracetam Hydrazide, now apparently lost. Three years later, a Ceretropic co-owner recalled that a thread by Isochroma-Reborn had drawn his attention to the compound. He considered adding a phenyl group, suggested it to a supplier, and Ceretropic eventually sold Phenylpiracetam Hydrazide, without animal or human studies. How much of this development can be traced directly to Isochroma's original proposal remains uncertain.

His experiments also became increasingly physiological. Confronted with low measured testosterone, persistent physical limitations and what he understood as premature aging, he investigated and administered hormonal substances, documenting his endocrine self-treatment on Longecity and T-Nation. Later he constructed high-output artificial lighting systems and began treating indoor illumination as another physiological intervention, capable of changing sleep, mood and everyday functioning:

"The PHOTONIC DRUG is the best Nootropic: it's measured in LUMENS instead of MILLIGRAMS."

His writing is worth reading beyond the experimental reports. Especially in his later years, a discussion of receptor pharmacology or dosage calculations could suddenly turn into political argument, speculative technology, elaborate prose or verse. Some posts are inventive, others obscure, contradictory or difficult to follow. The language can become extravagant, full of technical imagery and peculiar turns of phrase, sometimes barely resembling an ordinary forum contribution. Whether the substances had anything to do with this is impossible to establish. His fascination with unusual ideas and his experiments with language had begun years before his nootropics use.

His life outside nootropics was almost as unusual:

  • Court records, 2000–2001: a cannabis cultivation case in which he challenged the proceedings ("under protest"), plus a contemporary letter to the editor defending bodily autonomy.
  • Video business, 2004: IsoChroma Video Compression, a small video-processing business in Victoria.
  • Doom9: years of scripts, codec tests and bug investigations. For a single episode of Noir, he spent fourteen days manually working through 35,089 anime frames, selecting the best among nearly identical images.
  • Anime projects: the work fed into ChromaSubs, a release group, and Animescenes, an archive of screenshots of ruins, cities, technological environments and artificial light.
  • AVSForum: meticulously organized threads tracking LCD, plasma and OLED technology, manufacturing capacity, prices and industry developments. The OLED thread he opened in 2006 was still being linked in 2025.
  • Blog: World of Decline: The Beauty of a Declining World, on Peak Oil, abandoned infrastructure, technological decline and artificial environments.
  • Other experiments: unusual technical devices, video-processing methods that other users received with open scepticism, and dreams in which he inspected imaginary display technologies down to their pixel structure.

The essay is divided into three chapters and a coda. Chapter I reconstructs his biography, video work and technical projects. Chapter II follows his body as an experimental apparatus, from Longecity and piracetam through racetam procurement, experimental substances and endocrine self-treatment to artificial light. Chapter III examines Isochroma-Reborn on Reddit, his political writing and his attempts to diagnose the wider world. The Coda looks at what survived him and how I found him in the first place.

What I'm still looking for. Much of his biography survives only through scattered posts and second-hand recollections, and I've tried to distinguish documented facts from uncertain details. Specifically, I'd be grateful for:

  • his lost BrainMeta post on Piracetam Hydrazide, possibly relevant to the later development of Phenylpiracetam Hydrazide
  • the original Bluelight posts
  • logs or screenshots from his IRC channel #ARTTherapy on Rizon
  • his posts on 1Fast400 and BrainMeta
  • anyone who knew him, corresponded with him or had direct involvement in the early racetam supply networks (including u/IsochromasSuccessor, if you read this)

Memories, corrections and missing sources are all welcome, especially material that never made it into the public archives.


r/Nootropics • • 3d ago

Seeking Advice Recommend Investors Pitch stack

6 Upvotes

In the beginning of December, I have my first-ever meeting to pitch to a board of investors. My memory is not good and neither is my verbal fluency + anxiety. I need help on a recommended stack leading up to the pitch for memory, and on pitch day for verbal fluency, memory recall, and anxiety. I was thinking I stay on my brom and tak throughout, and add Aniracetam before the pitch. Would this be good? Or should I add or remove any other compounds?


r/Nootropics • • 3d ago

Discussion Ways to freeze/shutdown? How do you get out of this?

11 Upvotes

Hi, I'm stuck in a mixed freeze/shutdown state and derealization and depersonalization and anxiety. Leaving the house causes me great anxiety and overstimulation, I have such a sensitive nervous system at the moment, extremely sensitive. All stimulants in minimal doses make him feel worse.

I did too many somatic techniques and this caused my symptoms to worsen.

Do you have any supplements to get out of this state?


r/Nootropics • • 3d ago

Experience What do you think of my stack for ADHD and addiction/fatigue?

8 Upvotes

I take;

75mcg dose of vitamin D3

1000mg vitamine B3 niacin

Complex of high dose zinc, magnesium and calcium

Magnesium bisglycinate (high dose, 750/1000mg?)

Lions mane high dose (not sure 10, drops)

Vitamin B12 (not sure how much)

Just bought an energy booster since my new job doesn't allow coffee during work time :/ with: Guarana+maté+green tea, maca, Ashwagandha , vitamin c and natural caffeine (all in one pill).

I will also start with 1000/1500mg of NAC and cycle it to prevent anhedonia for my addictions

I take 20mg of Vyvanse and once I'm doing better I will taper off.

My main problems are: extreme fatigue, hair loss, recovering from burn out (working too much 50/60h on minimum wage), joint pain, addiction to coffee and nicotine, scatterbrained ADHD, brain fog.

I already avoid sugar and gluten, will need to improve on eating more.

Does anyone have some constructive feedback or health with similar health issues? I'm a woman, 25 and I'm 55kg/167cm. Not sure if it's relevant lol.


r/Nootropics • • 3d ago

Seeking Advice Does Aniracetam actually work?

3 Upvotes

I was going to start Aniracetam for verbal fluency, but I was doing some research and in the 2014 blind study, Aniracetam did not change the cognitive and affective behaviours in mice. This made me skeptic and a bit hesitant if it actually works in humans or if it’s placebo. If anyone has any info or studies they could direct me to I would appreciate it. Also, anyone with personal experience to speak on it would be great.


r/Nootropics • • 3d ago

Seeking Advice Saffron Extract - 265mg of Saffron??

4 Upvotes

I just bought a bottle off Saffron extract capsules which says it is 3:1, having 88.5mg equivalent to 265.5mg of Saffron. The brand is SM Nutrition. I never see dosages as high as 265.5mg mentioned anywhere but dosages around the range of 88.5mg are mentioned all the time, so I'm not sure how much to take. When people mention dosages here do they refer to a 3:1 extract? Or not? Is a dose equivalent to 265.5mg of saffron really high?