r/longevity • u/Slow_cpu • 7h ago
Mechanism revealed behind the positive effects of cold temperatures on delaying aging and preventing age-related diseases
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r/longevity • u/lunchboxultimate01 • Jan 01 '26
Read Me: Intro, Resources, and Materials
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With global average life expectancy at 73 years, age-related ill health is the main driver of healthcare costs, loss of independence, and disability in most countries. Although human biology is complex and there are hundreds of age-related pathologies, the biology of aging can be categorized into a much smaller number of categories and potential treatments. Medically intervening in aspects of aging biology has the potential to increase healthy lifespan in humans and ameliorate, prevent, or reverse age-related health decline and disability.
The umbrella term "longevity" covers a wide range of interests from simple lifestyle advice to hypothetical biomedical rejuvenation to significantly increase healthy lifespan. Beware, as "longevity" is also readily used by quacks and grifters who promote and sell unproven treatments. Because so many subs cover lifestyle (diet, exercise, etc.), it is not allowed in posts here. For those interested in lifestyle, two useful resources are the free substacks of Dr. Eric Topol and Dr. Christin Glorioso, (choose "No thanks" if you don't want to provide your email).
The focus of this sub is biomedical research targeting aspects of the biology of aging, including medical interventions that aim to go through clinical trials and regulatory approval. Continue reading for examples.
Table of Contents
- Introductory presentations to the field
- Introductory academic papers
- Ethical arguments
- University labs
- Podcasts
- Video lectures and presentations
- Government agencies and programs
- Examples of biotech companies in the field
- Academic and nonprofit research organizations
- Think tank and advocacy organizations
Introductory presentations to the field
- "Ageless" by Andrew Steele (video)
- Field Guide to Longevity Content | Norn Group (essay)
- Biology of Aging Intro Lectures | American Aging Association (video playlist)
Introductory academic papers
- Hallmarks of aging: An expanding universe
- The Divide-and-Conquer Approach to Delaying Age-Related Functional Decline: Where Are We Now?
- The economic value of targeting aging
Ethical arguments
- Aging, Equality and the Human Healthspan
- In Favor of Efforts to Extend the Human Lifespan
- The Ethics Case for Longevity Science
University labs around the world
For those interested in pursuing advanced degrees in the field, this Google Sheet is several years old but is a good starting point for labs around the world.
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Below are examples of organizations and additional material. For a comprehensive website on resources and more, see https://agingbiotech.info/ maintained by angel investor and longevity advocate Karl Pfleger.
Podcasts
- Buck Institute Podcast
- H-SPAN Podcast by Alliance for Longevity Initiatives (A4LI)
- Longevity Science with Dr. Matt Kaeberlein
- Scientist Spotlight by A4LI
- Translating Aging from BioAge Labs
Video lectures and presentations
- Aging Research and Drug Discovery (ARDD)
- Alliance for Longevity Initiatives
- Biomarkers of Aging Consortium
- Buck Institute for Research on Aging
Government agencies or government-sponsored organizations
- APRA-H BIOGAMI | BIOmolecular Grammar for protein Aggregation Modulation and Intervention
- ARPA-H FRONT | Functional Repair of Neocortical Tissue
- ARPA-H PROSPR | Proactive Solutions for Prolonging Resilience
- APRA-H NITRO | Novel Innovations for Tissue Regeneration in Osteoarthritis
- APRA-H PRINT | Personalized Regenerative Immunocompetent Nanotechnology
- Hevolution
- National Institute on Aging, Division of Aging Biology
- Onco-Aging Consortium | NIA and NCI
Examples of biotech companies in the field
- Altos Labs
- BioAge Labs
- Cambrian Bio
- Cyclarity Therapeutics
- Juvena Therapeutics
- Life Biosciences
- Loyal
- Retro Bio
- Rubedo Life Sciences
Academic and nonprofit research organizations (please consider donating)
Ex-USA
- British Society for Research on Ageing
- Canadian Translational Geroscience Network
- Cluster of Excellence for Aging Research at the University of Cologne
- Dutch Society for Research on Ageing | De Nederlandse Vereniging voor Verouderingsonderzoek
- European Federation for Aging Research
- European Research Institute for the Biology of Aging
- Geroscience Research Center | ジェロサイエンス研究センター
- Japan Autophagy Consortium | 日本オートファジーコンソーシアム
- Max Planck Institute for Biology of Ageing | Max-Planck-Institut für Biologie des Alterns
- Nordic Aging Society
USA
- Academy of Geroscience
- American Aging Association
- American Federation for Aging Research
- Biomarkers of Aging Consortium
- Buck Institute
- Dog Aging Project
- Lifespan Research Institute
- Longevity Escape Velocity (LEV) Foundation
- Longevity Science Foundation
- Methuselah Foundation
- Midwest Aging Consortium
- Nathan Shock Centers
- Vita DAO
Think tanks and advocacy organizations
Ex-USA
- Longevity Initiative (UK)
- Vetek Association (Israel)
USA
r/longevity • u/Slow_cpu • 1d ago
Sea cucumber-inspired gel could help heal damaged tissue in humans. Waterloo researchers develop a new material that supports tissue regeneration, with promising results in preclinical studies...
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r/longevity • u/lunchboxultimate01 • 1d ago
Aging Research and Drug Discovery (ARDD) 2026 Conference Recordings
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ARDD 2026 recordings are being uploaded to their YouTube channel (https://www.youtube.com/@ardd3628/videos). Feel free to post individual videos you find interesting, but try to avoid reposts.
r/longevity • u/the_mit_press • 1d ago
[crosspost] AMA with Dr. Saul Newman, research fellow at the University of Oxford Institute of Population Ageing and author of Morbid: Debunking Modern Longevity Science
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r/longevity • u/Slow_cpu • 1d ago
Unravelling DNA repair: uOttawa-led team shows how cells protect their genetic blueprint
eurekalert.org
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r/longevity • u/Slow_cpu • 1d ago
Psychological symptoms may drive menopause-related workforce attrition. New study suggests that psychological symptoms of menopause, rather than physical symptoms, are the primary drivers of increased turnover among perimenopausal and postmenopausal employees...
eurekalert.org
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r/longevity • u/Slow_cpu • 2d ago
New 4D biofabrication technology holds promise for tissue engineering, wound healing...
eurekalert.org
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r/longevity • u/barrel_master • 4d ago
CNN: Could GLP-1 drugs be anti-aging medications?
295
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r/longevity • u/towngrizzlytown • 4d ago
Field Notes from ARDD and Biomarkers of Aging Consortium 2026 Conferences | Martin Borch Jensen
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Finding and testing new longevity medicines, with updates on research, pharma involvement, biomarkers for human trials and the limits of AI.
r/longevity • u/Slow_cpu • 5d ago
New control theory framework proposes a safer approach to aging drug discovery. 'Existing aging theories describe what changes with age but do not prescribe how to intervene.'
40
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r/longevity • u/Slow_cpu • 6d ago
Reversing age by reprogramming gene expression networks. Aging-specific screening platform identifies gene with multifaceted rejuvenation potential that extends health- and lifespan in mice.
170
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r/longevity • u/towngrizzlytown • 6d ago
Clinical trials for aging | Update on ARPA-H PROSPR
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r/longevity • u/Livid_Parsnip_2816 • 6d ago
SRSF1 expression reduced frailty progression by 44% and extended median lifespan by 14% in aged mice
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The peer-reviewed study identified SRSF1 through a transcriptomic screening platform; the lifespan experiment was small, with 9–10 mice per group, so the result is promising but still early.
r/longevity • u/ptword • 5d ago
I’ve been a doctor for 30 years – our obsession with living longer has gone too far
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r/longevity • u/Slow_cpu • 7d ago
Earlier menopause linked to faster biological ageing, NUS Medicine study finds
eurekalert.org
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r/longevity • u/Slow_cpu • 8d ago
Mount Sinai scientists to send human tissue models into space to study brain, heart health, and aging in microgravity
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r/longevity • u/fchung • 9d ago
Why big dogs age faster: « Large-scale Dog Aging Project reveals how 'jumping genes' underly differences in lifespan and disease risks across breeds. »
news.asu.edu
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r/longevity • u/user_-- • 9d ago
Did anyone attend Boston Longevity Week? How was it?
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A string of longevity meetings (ARDD, Biomarkers of Aging, etc.) just wrapped up in Boston and I have to assume some folks here showed up. Please share any highlights!
r/longevity • u/mlhnrca • 10d ago
Tryptophan Absorption Declines During Aging: Can It Be Improved?
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r/longevity • u/lunchboxultimate01 • 11d ago
Life Biosciences Announces First-in-Human Data from Ongoing Phase 1 Trial Evaluating ER-100 (Partial Epigenetic Reprogramming) in Optic Neuropathies
120
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r/longevity • u/Slow_cpu • 14d ago
International, cross-sector collaboration commits nearly $2 billion to build foundational data for AI models to predict and treat disease
eurekalert.org
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r/longevity • u/here_now_be • 16d ago
New molecule restores memory in animals with Alzheimer's' disease
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r/longevity • u/mlhnrca • 17d ago
The Best Human Longevity Lab (That You've Probably Never Heard Of)
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