What do Albert Einstein, Virginia Woolf, Stephen King, Henry David Thoreau and Friedrich Nietzsche have in common?
They all credit walking as essential for helping their creative thinking.
Though walking may seem mundane, it has many health benefits, including improving longevity and making your brain younger. Research also shows that walking helps people come up with an essential ingredient for creativity.
“It really helps you generate ideas, novel ideas, original ideas,” said Alex Thabane, a researcher at McMaster University and the lead author of a recent meta-analysis that looked at walking and creativity.

What kids watch — and parental involvement — may matter as much as time spent on screens

The results, published in the American Cancer Society journal CANCER, revealed that patients who received 1,000 mg of oral vitamin C every day for one year experienced fewer adverse events during the study and its follow-up period. The supplement also changed the levels of certain immune signaling molecules, known as cytokines, in ways associated with more favorable outcomes. These changes suggest that vitamin C could influence inflammation-related processes involved in the growth and progression of abnormal blood cells.

Although vitamin C did not significantly affect the rate at which abnormal blood cells expanded, the researchers identified an encouraging result. An exploratory analysis showed that participants who received vitamin C were significantly more likely to be alive after approximately three years of follow-up than those who took a placebo. Scientists emphasize that this potential survival benefit must be verified in a larger phase 3 clinical trial.

"We are tremendously excited and cautiously optimistic that our results could one day translate into a simple way to improve care and outcomes for people with pre-leukemia disorders," said Peter A. Jones, Ph.D., D.Sc. (hon), a distinguished professor at Van Andel Institute. Jones is also a co-corresponding author of the research and co-leader of the VAI-SU2C Epigenetics Dream Team.

"Our approach reflects a growing emphasis on cancer interception -- intervening before cancer becomes established. We are working to build on the trial findings by exploring how exactly vitamin C interacts with pre-cancerous cells, including the idea that it may help restore normal epigenetic function in blood cells at risk of becoming leukemia."

The study enrolled 109 patients with either clonal cytopenia of undetermined significance (CCUS) or myelodysplastic syndrome (MDS). Both conditions can develop into acute myeloid leukemia (AML), an aggressive form of blood cancer that is often difficult to treat. The likelihood of developing CCUS and related blood disorders rises with age, making these conditions particularly common among older adults.

To determine whether vitamin C might offer benefits, researchers randomly divided participants into two groups. One received 1,000 mg of vitamin C by mouth each day for 12 months. The other received a placebo designed to be indistinguishable from the supplement in appearance, taste, and smell, but containing no vitamin C.

Neither the participants nor the clinical staff knew who was receiving vitamin C until the study concluded. This double-blind, randomized, placebo-controlled approach is considered the gold standard in clinical research because it reduces potential bias and allows investigators to assess treatment effects more objectively.

The research was carried out at four hospitals: Copenhagen University Hospital-Rigshospitalet, Copenhagen University Hospital-Herlev, Aalborg University Hospital, and Keck Hospital of the University of Southern California.

What makes EVITA particularly notable is that it was the first randomized, double-blind, placebo-controlled trial to investigate oral vitamin C in patients with conditions that can precede leukemia or with lower-risk myeloid cancers. Earlier studies had primarily examined vitamin C administered intravenously and had focused on solid tumors rather than precancerous blood disorders or early-stage blood malignancies.

EVITA instead evaluated a daily oral dose comparable to that available in many over-the-counter vitamin C supplements.

Blood samples collected throughout the study allowed researchers to track participants' vitamin C concentrations and determine whether supplementation corrected deficiencies.

At the beginning of the trial, more than half of the participants had insufficient vitamin C levels. Among those assigned to the supplementation group, blood concentrations returned to normal after they began taking vitamin C.

For patients living with conditions that could eventually develop into leukemia, the possibility of an accessible intervention is especially important. In many cases, physicians have little choice but to monitor the disease and watch for signs that it is progressing.

"The standard approach for patients with pre-cancer blood disorders is to monitor their blood cell counts over time. This is, understandably, very frustrating -- no one wants to hear that they have a condition that increases leukemia risk but there's nothing that can be done other than watch and wait," said Casey O'Connell, M.D., FACP, the Lawrence and Jane Kelly Chair in Hematology at the University of Southern California and lead clinician at USC's trial location.

"The EVITA trial took on this challenge by exploring vitamin C's potential to address the underlying factors that drive leukemia development."

Scientists have investigated whether vitamin C could play a useful role in cancer treatment for more than seven decades. For much of that time, the evidence remained uncertain because studies produced inconsistent findings and employed different experimental methods.

During the past decade, however, improved research technologies have revealed that vitamin C has important functions beyond its familiar roles in nutrition and immunity. In particular, scientists have uncovered its involvement in controlling gene activity and guiding normal cell development.

One of the most important discoveries concerns TET2, an enzyme that helps prevent cancerous growth by controlling whether particular genes are switched "on" or "off." Vitamin C supports the activity of this enzyme, which helps maintain normal patterns of gene regulation.

Mutations affecting TET2 are frequently found in leukemia and related blood disorders. When the enzyme's normal function is disrupted, abnormal cells can gain an opportunity to multiply and potentially develop into cancer.

Experiments using cancer models have provided additional evidence of vitamin C's possible protective effects. These studies found that supplementation could interfere with cellular changes associated with cancer and slow the progression of leukemia. Notably, the strongest effects appeared when vitamin C was introduced before cancer had become established.

This research helped inspire the idea of using vitamin C as a form of early intervention, potentially targeting the biological changes that precede the development of leukemia.

Before launching EVITA, the VAI-SU2C Epigenetics Dream Team conducted a pilot clinical study in 2016 to determine whether taking vitamin C orally could meaningfully raise its concentration in the blood.

The initial findings suggested that oral supplementation was a practical approach. Encouraged by those results, the researchers launched the phase 2 EVITA trial in 2017.

"This early work was critical because it offered a foundation from which to develop the present trial," said Stine Ulrik Mikkelsen, M.D., Ph.D., the study's first author and a clinician researcher in Grønbæk's laboratory.

"Vitamin C is important because it is involved in a range of biological functions, including the activity of enzymes that regulate normal cell function."

Researchers are continuing to examine the EVITA data to better understand the biological processes that might explain why patients receiving vitamin C showed improved survival.